Pharmacokinetics of Lansoprazole in Rats Sept. 2020-Nov. 2020
School of Pharmacy, China Pharmaceutical University
Team Member, supervise by Dr. Wang Hong
l Graspe the mechanism of action of lansoprazole in rats an esigne experiment scheme
l Collecte rat venous bloo from ocular funus after aministration an pre-treate the samples by centrifugation
l Determine the rug concentration in samples by HPLC (high performance liqui chromatography) an valiate the methoology
l Calculate the pharmacokinetic parameters an analyze the matters neeing attention in experimental operation an factors that may affect experimental results
The Preliminary Experiment on the Development of Anti-tumor Vaccine Sept. 2019-Dec. 2019
School of Life Science an Technology, China Pharmaceutical University
Lab Member, supervise by Prof. Cao Rongyue
l Designe a protein extraction metho base on relevant literature
l Extracte the protein macromolecules from grass carp scales
l Collecte an sorte out experimental ata for subsequent research an evelopment of the anti-tumor vaccine
l Main experimental methos: ultrasonic-assiste extraction, centrifugation, ialysis technique
Design, Synthesis an Bioactivity Evaluation of a Novel PARP Inhibitor with MDR Reversal Activity
Institute of Pharmaceutical Sciences, China Pharmaceutical University
Team Leaer, supervise by Prof. Qian Hai Apr. 2019-Nov. 2019
l Designe an synthesize a novel PARP (poly ADR-ribose polymerase) inhibitor molecule with MDR (multi-rug resistance) reversal activity
l Confirme the structure of the compoun by 1H-NMR (proton nuclear magnetic resonance) an LC-MS (liqui chromatography-mass spectrometry)
l Evaluate the anti-tumor activity of the compoun incluing in vitro cytotoxicity an MDR reversal activity
l Main experimental methos: column chromatography, thin-layer chromatography, 1H-NMR spectroscopic metho, LC-MS metho, MTT assay